Vascular Smooth Muscle Updated

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Vascular smooth muscle updated.

• This brief review of the rapidly developing research on vascular smooth muscle presents the state of the art as I see it from within my own frame of reference. For a more objective, detailed insight into the workings of vascular smooth muscle, several substantial reviews and compendiums may be read (1-7). The mechanical events responsible for the contraction of vascular smooth muscle are asso...

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Recent observations in our laboratory suggest that angiotensin II (Ang II) is a bifunctional vascular smooth muscle cell (VSMC) growth modulator capable ofinducing hypertrophy or inhibiting mitogen-stimulated DNA synthesis. Because transforming growth factor-,61 (TGFfIi) has similar bifunctional effects onVSMC growth, we hypothesized that autocrine production of TGFfti may mediate the growth mo...

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In 1653, the English physician William Harvey published the first comprehensive study of blood vessels, De Motu Cordis.1 This classic treatise delineated the directions of blood flow, differences between veins and arteries, functions of venous ''valves,' and anatomy of the systemic and pulmonary circulations. By the 19th century, the major layers constituting blood vessels were identified and o...

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8030 Vascular Smooth Muscle

Caldesmon, a major actinand calmodulin-binding protein, has been identified in diverse bovine tissues, including smooth and striated muscles and various nonmuscle tissues, by denaturing polyacrylamide gel electrophoresis of tissue homogenates and immunoblotting using rabbit anti-chicken gizzard caldesmon. Caldesmon was purified from vascular smooth muscle (bovine aorta) by heat treatment of a t...

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Segments of dog carotid artery were held at in-situ length and studied in vitro after excitation of the muscle with norepinephrine and after poisoning of the muscle with potassium cyanide. In-situ length corresponded to a longitudinal strain of .57 ± .02 relative to the unstretched length. The longitudinal elastic modulus was about 4.1 X 10 dyn/cm at in-situ length and zero transmural pressure....

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1973

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.32.6.665